神戸大学大学院農学研究科
応用動物学講座
動物形態機能学教室

原著論文

2011年以降


Arai M, Mantani Y, Nakanishi S, Haruta T, Nishida M, Yuasa H, Yokoyama T, Hoshi N, Kitagawa H. Morphological and phenotypical diversity of eosinophils in the rat ileum. Cell Tissue Res., in press, 2020

Yasuda R, Aachi S, Okonogi A, Anzai Y, Kamiyama T, Katano K, Hoshi N, mogi K, Natsume T. Cell stress reduction by a novel perfusion-culture system using commercial culture dish. Applied Sci. 10: 95, 2020

Hasegawa C, Yokoyama T, Umemura Y, Kawanishi K, Miura Y, Takada N, Ohno S, Onaru K, Omotehara T, Hirano T, Mantani Y, Miki T, Hoshi N. Establishment of an organ culture system to induce Sertoli cell differentiation from undifferentiated mouse gonads. J Vet Med Sci. 2020 Feb 21. doi: 10.1292/jvms.20-0036. [Epub ahead of print]

Onaru K, Ohno S, Kubo S, Nakanishi S, Hirano T, Mantani Y, Yokoyama T, Hoshi N. Immunotoxicity evaluation by subacute oral administration of clothianidin in Sprague-Dawley rats. J Vet Med Sci. 2020 Jan 27. doi: 10.1292/jvms.19-0689. [Epub ahead of print]

Takada T, Yoneda N, Hirano T, Onaru K, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Nimako C, Ishizuka M, Ikenaka Y, Hoshi N. Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice. J Vet Med Sci. 2020 Jan 27. doi: 10.1292/jvms.19-0635. [Epub ahead of print]

Ohno S, Ikenaka Y, Onaru K, Kubo S, Sakata N, Hirano T, Mantani Y, Yokoyama T, Takahashi K, Kato K, Arizono K, Ichise T, Nakayama SMM, Ishizuka M, Hoshi N. Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice. Toxicol Lett. 2020, 322: 32-38. doi: 10.1016/j.toxlet.2020.01.003. Epub 2020 Jan 7.

Hirano T, Minagawa S, Furusawa Y, Yunoki T, Ikenaka Y, Yokoyama T, Hoshi N, Tabuchi Y. Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SH-SY5Y cells. Toxicol Appl Pharmacol. 2019 Nov 15;383:114777. doi: 10.1016/j.taap.2019.114777. Epub 2019 Oct 15.

Yuasa H, Mantani Y, Miyamoto K, Nishida M, Arai M, Tsuruta H, Yokoyama T, Hoshi N, Kitagawa H. Effects of the expansion of bacterial colonies into the intervillous spaces on the localization of several lymphocyte lineages in the rat ileum. 2019, J Vet Med Sci. 81:555-566. doi: 10.1292/jvms.18-0734. Epub 2019 Feb 25.

Mantani Y, Haruta T, Nishida M, Yokoyama T, Hoshi N, Kitagawa H. Three-dimensional analysis of fibroblast-like cells in the lamina propria of the rat ileum using serial block-face scanning electron microscopy. J Vet Med Sci. 2019 Mar 30;81: 454-465. doi: 10.1292/jvms.18-0654. Epub 2019 Jan 29. (2019)

Yokoyama T, Miura Y, Yamamoto A, Hasegawa C, Kawanishi K, Takada N, Omotehara T, Hirano T, Mantani Y, Miki T, Hoshi N. Genetic differences between C57BL/6 substrains affect the process of testis differentiation in YPOS mice. 2019, J Vet Med Sci, 81: 608-611. DOI: 10.1292/jvms.18-0621. [Epub ahead of print]

Yokoyama T, Omoteahara T, Kubota N, Yanai S, Hasegawa C, Takada T, Hirano T, Mantani Y, Hoshi N. Identification of reference genes for quantitative PCR analyses in developing mouse gonads. J Vet Med Sci, 80: 1534-1539, 2018.

Yamamoto A, Omotehara, Miura Y, Takada T, Yoneda N, Hirano T, Mantani Y, Kitagawa H, Yokoyama T, Hoshi N. The mechanisms underlying the effects of AMH on Müllerian duct regression in male mice. 80: 557-567, 2018. doi: 10.1292/jvms.18-0023.

Takada T, Yoneda N, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Hoshi N. Verification of the causal relationship between subchronic exposures to dinotefuran and depression-related phenotype in juvenile mice. J Vet Med Sci, 80: 720-724, 2018. doi: 10.1292/jvms.18-0022. [Epub ahead of print]

Yoneda N, Takada T, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice. J Vet Med Sci, 80: 634-637, 2018. doi: 10.1292/jvms.18-0014. [Epub ahead of print]

Mantani Y, Nishida M, Yamamoto K, Miyamoto K, Yuasa Ho, Masuda N, Omotehara Tya, Tsuruta H, Yokoyama T, Hoshi N, Kitagawa H. Ultrastructural and immunohistochemical study on the lamina propria cells beneath Paneth cells in the rat ileum. 2018, Anat Rec, 301: 1074-1085. doi: 10.1002/ar.23778. [Epub ahead of print]

Masuda N, Mantani Y, Yuasa H, Yoshitomi C, Arai M, Nishida M, Qi W-M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. Immunohistochemical study on the distribution of β-defensin 1 and β-defensin 2 throughout the respiratory tract of healthy rats. 2018, J Vet Med Sci, 80: 395-404

Masuda N, Mantani Y, Yuasa H, Yoshitomi C, Nishida M, Arai M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. Immunohistochemical study on the secretory host defense system with lysozyme and secretory phospholipase A2 throughout rat respiratory tract. 2018, J Vet Med Sci, 80:323-332.

Kubota N, Yokoyama T, Hoshi N, Suyama M. Identification of a candidate enhancer for DMRT3 involved in spastic cerebral palsy pathogenesis. Biochem Biophys Res Commun, 2018 496:133-139.

Hirano T, Yanai S, Takada T, Yoneda N, Omotehara T, Kubota N, Minami K, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. NOAEL-dose of a neonicotinoid pesticide, clothianidin, acutely induce anxiety-related behavior with human-audible vocalizations in male mice in a novel environment. 2018, Toxicol Lett, 282: 57-63.

Yasuda R, Adachi S, Okonogi A, Anzai Y, Kamiyama T, Katano K, Hoshi N, Natsume T, Mogi K. Fabrication of a Novel Culture Dish Adapter with Recess Microstructure for Flow Control in a Closed Environment. App Sci, 2018 in press

Yuasa H, Mantani Y, Masuda N, Nishida M, Arai M, Yokoyama T, Tsuruta H, Hoshi N, Kitagawa H. Mechanism of M-cell differentiation accelerated by proliferation of indigenous bacteria in rat Peyer’s patches. 2017, J Vet Med Sci, 79(11): 1826-1835. [Epub ahead of print]

Yanai S, Hirano T, Omotehara T, Takada T, Yoneda N, Kubota N, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. Prenatal and early postnatal NOAEL-dose clothianidin exposure leads to a reduction of germ cells in juvenile male mice. 2017, J Vet Med Sci, 79(7): 1196-1203.

Omotehara T, Minami K, Mantani Y, Umemura Y, Nishida M, Hirano T, Yoshioka H, Kitagawa H, Yokoyama T, Hoshi N. Contribution of the coelomic epithelial cells specific to the left testis in the chicken embryo. Dev Dyn. 2017 Feb;246(2):148-156. doi: 10.1002/dvdy.24469.

Yuasa H, Mantani Y, Masuda N, Nishida M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. Differential expression of Toll-like receptor-2, -4 and -9 in follicle-associated epithelium from epithelia of both follicle-associated intestinal villi and ordinary intestinal villi in rat Peyer’s patches. 2017, J Vet Med Sci, 78(12):1797-1804.

石庭寛子,十川和博,安元研一,星信彦,関島恒夫. (2016): ダイオキシン汚染がアカネズミ個体群に及ぼす影響: 遺伝子マーカーを用いて個体群の反応を捉える試み.(特集1 生態系における汚染の動態と影響)日本生態学会誌 66: 69-79.

Umemura Y, Miyamoto R, Hashimoto R, Kinoshita K, Omotehara T, Nagahara D, Hirano T, Kubota N, Minami K, Yanai, S, Masuda N, Yuasa H, Mantani Y, Matsuo E, Yokoyama T, Kitagawa H, Hoshi N. (2015): Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XYPOS J. Vet. Med. Sci., 77: 1587-1598.

Hirano T, Yanai S, Omotehara T, Hashimoto R, Umemura Y, Kubota N, Minami K, Nagahara D, Matsuo E, Aihara Y, Shinohara R, Furuyashiki T, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. (2015): The combined effect of clothianidin and environmental stress on the behavioral and reproductive function in male mice. J. Vet. Med. Sci., 77: 1207-1215, 2015.

Kobayashi Y, Hirano T, Omotehara T, Hashimoto R, Umemura Y, Yuasa H, Masuda N, Kubota N, Minami K, Yanai, S, Ishihara-Sugano M, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. (2015): Immunohistochemical Analysis of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Toxicity on the Developmental Dentate Gyrus and Hippocampal Fimbria in Fetal Mice. J. Vet. Med. Sci., 77: 1355-1361, 2015.

Mantani Y, Ito E, Nishida M, Yuasa H, Masuda N, Qi WM, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. (2015): Ultrastructural study on the morphological changes in indigenous bacteria of mucous layer and chyme throughout the rat intestine. J. Vet. Med. Sci., 77: 1121-1128, 2015.

Takahara E, Yuasa H, Nishida M, Mantani Y, Udayanga KGS, Qi WM, Takeuchi T, Yokoyama T, Hoshi N, Kitagawa H. (2015): Immunohistochemical and histoplanimetrical study on the endothelial receptor involved in transportation of minute chylomicrons into subepithelial portal blood in intestinal villi of the rat jejunum. J. Vet. Med. Sci., 77: 387-393.

Tabuchi Y, Yunoki T, Hoshi N, Suzuki N, Kondo T. (2014): Genes and gene networks involved in sodium fluoride-elicited apoptosis accompanying endoplasmic reticulum stress in oral epithelial cells. J. Mol. Sci., 15: 8959-8978.

Mantani Y, Yuasa H, Nishida M, Takahara E, Omotehara T, Udayanga KGS, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. (2014): Peculiar composition of epithelial cells in follicle-associated intestinal crypts of Peyer’s patches in the rat small intestine. J. Vet. Med. Sci., 76: 833-838.

Hoshi N, Hirano T, Omotehara T, Tokumoto J, Umemura Y, Mantani Y, Tanida T, Warita K, Tabuchi Y, Yokoyama T, Kitagawa H. (2014): Insight into the mechanism of reproductive dysfunction caused by neonicotinoid pesticides. Biol. Pharm. Bull., 37: 1439-1443.

Mantani Y, Nishida M, Yuasa H, Yamamoto K, Takahara E, Omotehara T, Udayanga KGS, Kawano J, Yokoyama T, Hoshi N, Kitagawa T. (2014): Ultrastructural and histochemical study on the Paneth cells in the rat ascending colon. Anat. Rec., 297: 1462-1471.

Hirano T, Kobayashi Y, Omotehara T, Tatsumi A, Hashimoto R, Umemura Y, Nagahara D, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. (2014): Unpredictable chronic stress-induced reproductive suppression associated with the decrease of kisspeptin immunoreactivity in male mice. J. Vet. Med. Sci., 76: 1201-1208.

Omotehara T, Smith CA, Mantani Y, Kobayashi Y, Tatsumi A, Nagahara D, Hashimoto R, Hirano T, Umemura Y, Yokoyama T, Kitagawa H, Hoshi N. (2014): Spatiotemporal expression patterns of doublesex and mab-3 related transcription factor 1 in the chicken developing gonads and Müllerian ducts. Poult. Sci., 93: 953-958.

Takahara E, Yuasa H, Nishida M, Mantani Y, Udayanga KGS, Qi WM, Takeuchi T, Yokoyama T, Hoshi N, Kitagawa H. (2014): Immunohistochemical and histoplanimetrical study on the endothelial receptor involved in transportation of minute chylomicrons into subepithelial portal blood in intestinal villi of the rat jejunum. J. Vet. Med. Sci., 77: 387-393.

Warita K, Mitsuhashi T, Hoshi N, Ohta K, Suzuki S, Takeuchi Y, Miki T. (2014): A unique pattern of bisphenol a effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44. Arh. Hig. Rada. Toksikol., 65: 293-299.

Tabuchi Y, Wada S, Ikegame M, Kariya A, Furusawa Y, Hoshi N, Yunoki T, Suzuki N, Takasaki I, Kondo T, Suzuki Y. (2014): Development of oral epithelial cell line ROE2 with differentiation potential from transgenic rats harboring temperature-sensitive simian virus40 large T-antigen gene. Exp. Anim., 63:31-44.

Tanida T, Tasaka K, Akahoshi E, Ishihara-Sugano M, Saito M, Kawata S, Danjo M, Tokumoto J, Mantani Y, Nagahara D, Tabuchi Y, Yokoyama T, Kitagawa H, Kawata M, Hoshi N. (2014): Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin transactivates aryl hydrocarbon receptor-responsive element III in the tyrosine hydroxylase immunoreactive neurons of the mouse midbrain. J. Appl. Toxicol., 34: 117-126.

Maeda N, Okumura K, Tanaka E, Suzuki T, Miyasho T, Haeno S, Ueda H, Hoshi N, Yokota H. (2013): Downregulation of cytochrome P450scc as an initial adverse effect of adult exposure to diethylstilbestrol on testicular steroidogenesis. Environ. Toxicol., 29: 1452-1459.

Sakamoto Y, Okumura N, Koizumi N, Numata R, Kitano J, Yamamoto M, Komada T, Hoshi N. (2013): Ferret animal model of corneal endothelial dysfunction for evaluation of drug effect on corneal endothelial wound healing. Anim. Eye. Res., 32: 15-21.

Sakamoto Y, Okumura N, Koizumi N, Yamasaki K, Kitano J, Numata R, Komada T, Hoshi N. (2013): Ferrets as a new experimental animal model for corneal endothelial research. Anim. Eye. Res., 31: 3-11

Takahara E, Mantani Y, Udayanga KGS, Qi WM, Tanida T, Takeuchi T, Yokoyama T, Hoshi N, Kitagawa H. (2013): Ultrastructural demonstration of the absorption and transportation of minute chylomicrons by subepithelial blood capillaries in rat jejunal villi. J. Vet. Med. Sci., 75: 1563-1569.

Warita K, Mitsuhashi T, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y. (2013): Gene expression of epigenetic regulatory factors related to primary silencing mechanism is less susceptible to lower doses of bisphenol A in embryonic hypothalamic cells. J. Toxicol. Sci., 38: 285-289.

Warita K, Mitsuhashi T, Fukui S, Ohta K, Suzuki S, Miki T, Takeuchi Y, Yokoyama T, Kitagawa H, Sugawara T, Hoshi N. (2013): Immunohistochemical analysis of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) expressions in the testes of mice during fetal development. Reprod. Biol., 13: 92-95.

Takenaka A, Kashiwagi N, Maezono Y, Nakao T, Uwano Y, Kakizoe Y, Kinoshita K, Kusunoki H, Hoshi N. (2013) Study on the ejaculate characteristics and liquid storage of semen in the common bottlenose dolphin (Tursiops truncatus). J. Zoo Wildlife Med., 18: 107-114.

Mantani Y, Takahara E, Takeuchi T, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. (2013): Histoplanimetrical study on the relationship between invasion of indigenous bacteria into intestinal crypts and proliferation of epithelial cells in rat ascending colon. J. Vet. Med. Sci., 75: 939-947.

Tokumoto J, Danjo M, Kobayashi Y, Kinoshita K, Omotehara T, Tatsumi A, Hashiguchi M, Sekijima T, Kamisoyama H, Yokoyama T, Kitagawa H, Hoshi N. (2013): Effects of exposure to clothianidin on the reproductive system of male quails. J. Vet. Med. Sci., 75: 755-760.

Warita K, Mitsuhashi T, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y. (2013): In vitro evaluation of gene expression changes for gonadotropin-releasing hormone 1, brain-derived neurotrophic factor, and neurotrophic tyrosine kinase, receptor, type 2, in response to bisphenol A treatment. Congenit. Anom., 53: 42-45.

Yuji M, Fujimoto M, Qi WM, Takahara E, Mantani Y, Udayanga KGS, Takeuchi T, Warita K, Yokoyama T, Hoshi N, Kitagawa H (2012): Persorption of IgG-Fc-Coated Particulates from Intestinal Lumen into Portal Blood via Villous Columnar Epithelial Cells in Rat Small Intestine. J. Vet. Med. Sci., 74: 1447-1452.

Mantani Y, Yokoo Y, Kamezaki A, Udayanga KGS, Takahara E, Takeuchi T, Kawano J, Yokoyama T, Hoshi N, Kitagawa H (2012): Immunohistochemical detection of toll-like receptor-2, -4 and -9 in exocrine glands associated with rat alimentary tract. Vet. Med. Sci., 74: 1429–1438.

Warita K, Mitsuhashi T, Tabuchi Y, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y (2012): Microarray and gene ontology analyses reveal downregulation of DNA repair and apoptotic pathways in diethylstilbestrol-exposed testicular Leydig cells. J. Toxicol. Sci., 37: 287-295.

Udayanga KGS, Yamamoto K, Miyata H, Yokoo Y, Mantani Y, Takahara E, Kawano J, Yokoyama T, Hoshi N, Kitagawa H (2012): Alteration in the apoptosis process of rat esophageal epithelium with hyperproliferation of indigenous bacteria under a physiological condition. J. Vet. Med. Sci., 74: 597–605.

Warita K, Mitsuhashi T, Tabuchi Y, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y. (2012): Microarray and gene ontology analyses reveal downregulation of DNA repair and apoptotic pathways in diethylstilbestrol- exposed testicular Leydig cells. J. Toxicol. Sci., 37: 287-295.

Udayanga KGS, Miyata H, Yokoo Y, Qi WM, Takahara E, Mantani Y, Yokoyama T, Hoshi N, Kitagawa H. (2011): Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition. Histol. Histopathol., 26: 811-820.

Yokoo Y, Miyata H, Udayanga KGS, Qi WM, Takahara E, Yokoyama T, Kawano J, Hoshi N, Kitagawa H. (2011): Immunohistochemical study on the secretory host defense system of bactericidal peptides in rat digestive organs. J. Vet. Med. Sci., 73: 217-225.

Yokoo Y, Miyata H, Udayanga KGS, Qi WM, Takahara E, Yokoyama T, Kawano J, Hoshi N, Kitagawa H. (2011): Immunohistochemical and histoplanimetrical study on the spatial relationship between the settlement of indigenous bacteria and the secretion of bactericidal peptides in rat alimentary tract. J. Vet. Med. Sci., 73: 1043-1050.

Yokoyama T, Etoh T, Udayanga KGS, Qi WM, Warita K, Matsumoto Y, Miki T, Takeuchi Y, Hoshi N, Kitagawa H. (2011): Immunohistochemical detection of phosphatidylserine and thrombospondin on the denucleating erythroblasts in rat bone marrow. J. Vet. Med. Sci., 73: 949-952.

Mantani Y, Kamezaki A, Udayanga KGS, Takahara E, Qi WM, Yokoyama T, Kawano J, Hoshi N, Kitagawa H. (2011): Site differences of the Toll-like receptor expression in the mucous epithelium of rat small intestine. Histol. Histopathol., 26: 1295-1303.

Udayanga KGS, Yamamoto K, Miyata H, Yokoo Y, Mantani Y, Takahara E, Qi WM, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. (2011): Alteration in the apoptosis process of rat esophageal epithelium with hyperproliferation of indigenous bacteria un a physiological condition. J. Vet. Med. Sci., 74: 597-605.